氨基酸无公害药肥的研制

选用具有杀虫抑菌,促进作物生长的氨基酸螯合物为主体,复合从植物中提取的杀虫、杀菌、促生长的活性成分,制成无公害速效药肥。以喷施药肥为例,介绍原料筛分、配比、生产工艺、主要设备,喷施药肥用量及稀释倍数,肥效杀虫试验取得的良好效果,该产品有广泛应用前景。     

白术多糖对激发态小鼠体液免疫的效应研究

目的研究白术多糖对小鼠体液免疫应答效应的影响。方法将180只小鼠平均分为3个大组,每大组设置实验组和对照组2个小组,分别皮下注射白术多糖抗原、卵核抗原和生理盐水。2周后采血制备血清,用ELISA方法检测血清中相应的IgG抗体。结果未检测到多糖IgG抗体,卵核IgG抗体实验组与对照组血清抗体效价无明显差异。结论白术多糖无抗原性,对体液免疫血清IgG抗体无明显增强效应。     

饲料原料中有毒有害物质的综合毒性测定法初探

目的建立发光细菌综合毒性测定法,对实验动物饲料原料中有毒有害物质进行初筛.方法用发光细菌作指示生物,测定金属离子Pb2+,Zn2+,Cr+,Hg2+和毒性物质苯酚,灭害灵;以Hg2+为毒性对照物,测定10种饲料原料和3种人用食品.结果发光菌对有毒有害物质和金属离子敏感.在所测定的范围内,其发光强度随浓度增加而减弱,即相对抑光率增强,呈负线性相关,其相关系数在0.92以上;以Hg2+为毒性对照物,对10种饲料原料和3种人用食品进行测定,其中脱水蔬菜相对抑光率最大,为39.74%,相当于1.85×10-5%Hg2+的表征毒性,提示该样品可能受到农药和化肥等较严重的污染.结论发光细菌综合毒性测定法,可用于饲料原料中有毒有害物质的初筛,是一种快速、经济、有效的方法.     

HPLC法测定枸橼酸铋雷尼替丁及其片剂中雷尼替丁的含量

目的:建立HPLC测定枸橼酸铋雷尼替丁及其片剂中雷尼替丁含量的方法。方法:色谱柱为InertsilODS-3(4.6 mm×150 mm,5μm);磷酸盐缓冲液(取磷酸6.8 mL置1900 mL水中,加入50%氢氧化钠溶液8.6 mL,加水至2000 mL,用磷酸或50%氢氧化钠溶液调节pH至7.10±0.05)–乙腈(98∶2)及磷酸盐缓冲液–乙腈(78∶22)分别为流动相A、B,梯度洗脱;流速为1.2 mL.min-1,检测波长为230 nm,柱温为35℃;外标法。结果:本方法在2.5～200.4μg.mL-1范围内线性良好(r=0.9998),定量限为5 ng(以雷尼替丁计)。结论:本方法简便、灵敏、专属性好、结果准确,适用于枸橼酸铋雷尼替丁及其片剂中雷尼替丁含量的测定。     

生石膏治疗小儿发高烧36例

[目的]探讨生石膏对小儿发高烧的治疗效果。[方法]36例临床患者,均予以大剂量生石膏治疗,或适当加辅佐药配合治疗。[结果]36例患者用药后都达到了退烧的满意效果。其中24h内退烧者4例,占11.1%;24～48h退烧者25例,占69.4%;48h后退烧者7例,占19.5%。[结论]生石膏治疗小儿发高烧有较好疗效。     

GMP环境下的记录管理方法

论述了如何对记录体系进行管理,以避免美国和欧洲GMP检查中常见的记录管理缺陷.具体讨论了法规检查模型、假记录的严重后果、记录的设计、记录的生命周期管理(发放/回收、原始数据的完整性、存档管理)和趋势分析.     

医药化工原料药生产尾气处理设计技术探讨

分析了医药化工原料药生产过程中的尾气排放来源,介绍了医药化工原料药生产过程尾气处理的常用技术,着重分析了吸附法尾气处理技术及其工程设计要点.     

Probabilistic cumulative risk assessment of anti-androgenic pesticides in food

In this paper, we present a cumulative risk assessment of three anti-androgenic pesticides (vinclozolin, procymidone and prochloraz) using the relative potency factor (RPF) approach and an integrated probabilistic risk assessment (IPRA) model. RPFs for each substance were estimated for three reproductive endpoints (ano-genital distance, and weights of the seminal vesicles and the musculus levator ani/bulbocavernosus) in male rat foetuses exposed in utero. The cumulative dietary intake was estimated based on consumption data and residue data from the Netherlands. The IPRA model combines variability in both exposure and sensitivity between individuals into a distribution of individual margins of exposures (IMoEs) and IMoEs of 1 or less indicate a possible concern.     

Harmonisation of food consumption data format for dietary exposure assessments of chemicals analysed in raw agricultural commodities

In this paper, we present an approach to format national food consumption data at raw agricultural commodity (RAC) level. In this way, the data is both formatted in a harmonised way given the comparability of RACs between countries, and suitable to assess the dietary exposure to chemicals analysed in RACs at a European level. In this approach, consumption data needs to be converted to edible part of RAC (e-RAC) level using a RAC conversion database. To subsequently use this data in exposure assessments, both e-RACs and RACs analysed in chemical control programmes should be classified via a uniform system. Furthermore, chemical concentrations in RACs may need to be converted to e-RAC level using processing factors. To illustrate the use of this approach, we describe how the Dutch RAC conversion database was used to convert consumption data of four national consumption surveys to e-RAC level, and the use of the FAO/WHO Codex Classification system of Foods and Animal Feeds to harmonise the classification. We demonstrate that this approach works well for pesticides and glycoalkaloids, and is an essential step forward in the harmonisation of risk assessment procedures within Europe when addressing chemicals analysed in RACs by all national food control systems.